Developing Clinical Applications for Genome Data in Obsessive-Compulsive Disorder: The goal of this study is to explore development of genomic OCD prediction models, to validate these models with independent cases and controls, and to develop models to differentiate long-term course types.
Brain Function, Structure and Genes in Obsessive Compulsive Disorder: The goal of this study is to examine the cortical structure and functional activation in the regions implicated in OCD (orbitofrontal cortex, striatum, insula) in OCD-affected and healthy children and adolescents. A visuospatial priming task and a task-switching paradigm will be used in addition to DTI to record white matter structure and organization. A concurrent goal is to examine the relationship between brain structure and OCD-susceptibility genotypes in OCD-affected and healthy individuals.
Obsessive-Compulsive Foundation Genetics Collaborative Whole Genome Association Study: This multi-site study will be conducted by the OCF Genetics Collaborative. The goal is to conduct a whole genome association study to genotype 1 million single nucleotide polymorphisms along the DNA of 2500 OCD cases and their parents or controls. This is the first study of its kind to be conducted in OCD.
MGH/ McLean OCD Research Program Studies: The goal of this series is to examine clinical, genetic, and outcome correlates of severe refractory OCD.