• Stewart, S. Evelyn

    Titles

    Senior Clinician Scientist, CFRI
    Associate Professor, Division of Clinical & Behavioural Neurosciences, Department of Psychiatry, University of British Columbia
    Medical Director, Pediatric OCD Program (POP) and Consultant Psychiatrist
    Senior Scientist, BC Mental Health and Addictions Research Institute
    Lecturer, Harvard Medical School
    Non-Clinical Consultant, Massachusetts General Hospital

    Degrees / Designations
    MD
    Primary Area of Research
    Developmental Neurosciences & Child Health
    Genetics & Health
    Secondary Area(s) of Research
    Phone
    604-875-2000 x4725
    Fax
    Lab Phone
    Assistant
    Rhonda Ellwyn
    Assistant Phone
    604-875-2000 x4731
    Mailing Address

    A3-118, 950 West 28th Avenue
    Vancouver, BC  V5Z 4H4

    Affiliate Websites
    Research Areas
    • Obsessive-Compulsive Disorder (OCD)
    • Translational research
    • Genetics
    • GWAS
    • Anxiety disorders
    • Developmental trajectories
    • fMRI
    Summary

    Dr. Evelyn Stewart is an Associate Professor in the Department of Psychiatry, University of British Columbia and is the founding director of the Pediatric Obsessive-Compulsive Disorder Clinic and Research Program at BC Children and Women’s Health Centre. She is a clinical, genetic and neuroscience researcher, as well as a child and adult psychiatrist.  

    Her research focuses on genomic, phenotypic, and treatment aspects of childhood-onset neuropsychiatric disorders, such as obsessive-compulsive disorder (OCD). Dr. Stewart has authored over 50 original papers, reviews and chapters on genetic, clinical, and treatment aspects of OCD, Tourette's Disorder, and related illnesses. She sits on the Scientific Advisory Board of the International OCD Foundation, on the Medical Advisory Board of the Tourette Syndrome Association and is Co-director of the International OCD Foundation Genetics Collaborative.

    Current Projects

    Developing Clinical Applications for Genome Data in Obsessive-Compulsive Disorder: The goal of this study is to explore development of genomic OCD prediction models, to validate these models with independent cases and controls, and to develop models to differentiate long-term course types.

    Brain Function, Structure and Genes in Obsessive Compulsive Disorder: The goal of this study is to examine the cortical structure and functional activation in the regions implicated in OCD (orbitofrontal cortex, striatum, insula) in OCD-affected and healthy children and adolescents. A visuospatial priming task and a task-switching paradigm will be used in addition to DTI to record white matter structure and organization. A concurrent goal is to examine the relationship between brain structure and OCD-susceptibility genotypes in OCD-affected and healthy individuals.

    Obsessive-Compulsive Foundation Genetics Collaborative Whole Genome Association Study: This multi-site study will be conducted by the OCF Genetics Collaborative. The goal is to conduct a whole genome association study to genotype 1 million single nucleotide polymorphisms along the DNA of 2500 OCD cases and their parents or controls. This is the first study of its kind to be conducted in OCD.

    MGH/ McLean OCD Research Program Studies: The goal of this series is to examine clinical, genetic, and outcome correlates of severe refractory OCD.

    Selected Publications
    • Sampaio AS, Fagerness J, Crane J, Leboyer M, Delorme R, Pauls DL, Stewart SE. Association between Polymorphisms in GRIK2 gene and Obsessive-Compulsive Disorder: a Family-based Study. CNS Neuroscience & Therapeutics, 2011 Jun;17(3):141-147.

    • Shapiro LJ, Stewart SE. Pathological Guilt: A Persistent Yet Overlooked Treatment Factor in Obsessive-Compulsive Disorder. Ann of Clin Psychiatry, 2011;23(1):63-70.

    • Delucchi KL, Katerberg H, Stewart SE, Denys DA, Lochner C, Stack DE, den Boer JA, van Balkom AJ, Jenike MA, Stein DJ, Cath DC, Mathews CA. Latent class analysis of the Yale-Brown Obsessive-Compulsive Scale symptoms in obsessive-compulsive disorder. Compr Psychiatry, 2011;52(3):334-41.

    • Crane J, Fagerness J, Osiecki L, Gunnell B, Stewart SE, Pauls DL, Scharf JM, and the Tourette Syndrome International Consortium for Genetics. Family-Based Genetic Association Study of DLGAP3 in Tourette Syndrome. Am J of Med Gen. 2011;156(1):108-14.

    • Stewart SE, Hu YP, Hezel DM, Proujansky R, Lamstein A, Walsh C, Ben-Joseph EP, Gironda C, Jenike M, Geller DA, Pauls DL. Development and Psychometric Properties of the OCD Family Functioning (OFF) Scale. J Fam Psychol. 2011 Jun;25(3):434-43.

    • O'Rourke JA, Scharf JM, Platko J, Stewart SE, Illmann C, Geller DA, King RA, Leckman JF, Pauls DL. The Familial Association of Tourette’s Disorder and ADHD: The Impact of OCD Symptoms. Am J Med Genet B Neuropsychiatr Genet. 2011 Jul;156(5):553-60.

    • Stewart SE, Hezel D, and Stachon A. Assessment and Medication Management of Pediatric Obsessive-Compulsive Disorder. Drugs. 2012 May 7;72(7):881-93.

    • Stewart, SE.  Rage Takes Center Stage: Focus on an Under-appreciated Aspect of Pediatric Obsessive Compulsive Disorder. JAACAP, 2012 Jun; 51(6):569-571.

    • Egan CA, Marakovitz SE, O'Rourke JA, Osiecki L, Illmann C, Barton L, McLaughlin E, Proujansky R, Royal J, Cowley H, Rangel-Lugo M, Pauls DL, Scharf JM, Mathews CA; Tourette Syndrome Association International Consortium for Genetics. Effectiveness of a web-based protocol for the screening and phenotyping of individuals with Tourette syndrome for genetic studies. Am J Med Genet B Neuropsychiatr Genet. 2012 Dec;159B(8):987-96.

    • Scharf JM, Yu D, Mathews CA, Neale BM, Stewart SE, Fagerness JA, et al. Genome-wide Association Study of Tourette’s syndrome. Mol Psychiatry. 2013 Jun;18(6):721-8.

    • Stewart SE, Dongmei Y, Scharf JM, Neale BM, et al. Genome-wide Association Study of Obsessive-Compulsive Disorder. Mol Psychiatry. 2013 Jul;18(7):788-98. doi: 10.1038/mp.2012.85. Epub 2012 Aug 14. Erratum in: Mol Psychiatry. 2013 Jul;18(7):843. Davis, L K [added].

    • SE Stewart, C Mayerfeld, PD Arnold, JR Crane, C O’Dushlaine, JA Fagerness, et al. Meta-Analysis of Association between Obsessive-Compulsive Disorder and the 3’ Region of Neuronal Glutamate Transporter SLC1A1. Am J Med Genet B Neuropsychiatr Genet. 2013 Jun;162B(4):367-79.

    • Muir KE, McKenney KS, Connolly MB, and Stewart SE. A case report of obsessive-compulsive disorder following acute demyelinating encephalomyelitis. Peds, 2013 Sep;132(3):e771-4.

    • Nag, A., Bochukova, E. G., Kremeyer, B., Campbell, D. D., Muller, H., Valencia-Duarte, A. V., . . . Genetics, T. S. A. I. C. f. (2013). CNV Analysis in Tourette Syndrome Implicates Large Genomic Rearrangements in COL8A1 and NRXN1. PLoS One. 2013;8(3):e59061. Epub 2013 Mar 22. PMID: 23533600. (Published by the Tourette Syndrome Association International Consortium for Genetics of which SE Stewart is a member).

    • Davis LK, Yu D, Keenan CL, Gamazon ER, et al. Partitioning the heritability of tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. PLoS Genet. 2013 Oct;9(10). Epub 2013 Oct 24. PMID: 24204291.

    • Egan CA, Marakovitz SE, O'Rourke JA, Osiecki L, Illmann C, Barton L, McLaughlin E, Proujansky R, Royal J, Cowley H, Rangel-Lugo M, Pauls DL, Scharf JM, Mathews CA; Tourette Syndrome Association International Consortium for Genetics. Effectiveness of a web-based protocol for the screening and phenotyping of individuals with Tourette syndrome for genetic studies. Am J Med Genet B Neuropsychiatr Genet. 2012 Dec;159B(8):987-96. Epub 2012 Oct 22. PMID: 23090870.

    • Hu Y-P, Wehrly R, Gorrindo T, Hezel D, Gironda C, Jenike M, and Stewart SE. Gender Specific Short Stature in Male Adolescents with Obsessive-Compulsive Disorder. Journal of Obsessive-Compulsive and Related Disorders, July 2012 (in press).

    • Booth B, Hatters-Friedman S, Curry S, Ward H, Stewart SE. Obsessions of child murder: under-recognized manifestations of obsessive-compulsive disorder. J Am Acad Psychiatry Law, September 2012. (in press).

    • Sampaio, AS, McCarthy, KD, Mancuso, E, Stewart, SE, and Geller, DA. Validation of the University of São Paulo's Sensory Phenomena Scale - English version. Comprehensive Psychiatry. February 2014. (in press).
    Grants
    1. 2014-2016, CIHR Operating Grant, $175,485/year ($526,454 for 3 years), Neural Correlates in Childhood-onset Obsessive-Compulsive Disorder. The goal is to compare neural correlates in CO-OCD and unaffected, at-risk sibling (SIB) groups with matched healthy controls (HC), in order to evaluate both their suitability as trait markers of genetic risk (to better understand the disorder) and their potential utility in clinical settings (to better manage the disorder). Role: Principal Investigator.
    2. 2014-2015, CIHR Planning Grant, $25,000 (total), Establishing a Pediatric Obsessive Compulsive Disorder Research Network. The goal is to rapidly establish the first formal Canadian national network dedicated to research on Pediatric OCD, with a central aim of partnering researchers, stakeholders and decision-makers who will set priorities and develop a research plan that contributes to knowledge creation and knowledge translation addressing health system deficiencies with respect to pediatric OCD. Role: Principal Investigator.
    3. 2012-2020, MSFHR Clinical Research Scholar Award, $90,000/year or ($635,000 for 8 years), OCD translational multi-modal research program. The goal is to create an interdisciplinary, multimodal research program within the new Pediatric OCD clinic at B.C. Children’s Hospital. Role: Principal Investigator.
    4. 2010-current, NIH-RO1, Perspectives on Neuroimaging and Genetics from Parents of Children with OCD. The goal is to examine experiences of parents involved in Pediatric neuroimaging studies. Role: Co-Investigator.
    5. 2007-2014, Obsessive-Compulsive Foundation Genetics Collaborative Whole Genome Association Study. The goal is to conduct a whole genome association study to genotype 1 million single nucleotide polymorphisms along the DNA of 2500 OCD cases and their parents or controls. This is the first study of its kind to be conducted in OCD. Role: Co-Principal Investigator.
    Honours & Awards
    • 2009 Nominated for Excellence in Mentoring Award for 2008-2009, Massachusetts General Hospital
    • 2008-9 Travel Awardee American College of Neuropsychopharmacology
    • 2008 Research Colloquium for Junior Investigators
    • 2008 American Psychiatric Association
    • 2001 Resident nominee – Association of Chairs of Psychiatry of Canada Excellence in Research Award
    • 2001 Best Research Paper, Ottawa Psychiatry Resident Research Day
    • 2000 Best Resident Research Presentation, Ottawa Psychiatry Research Day
    • 2000 Resident nominee – Laughlin Fellowship
    • 2000 Best Canadian Child Psychiatry resident research project
    • 1999 Best Clinical Paper, Ottawa Pediatrics Resident Research Day
    • 1998 Chronic Care and Rehabilitation Award, Ottawa Resident Research Day
    • 1998 Wilson Fellowship Award 
    • 1996 Inaugural Hunter Medical Humanities Award "for outstanding contribution demonstrating qualities of caring and compassion in the care of patients."
    • 1996 Silver D. Award for contribution to student life, Dalhousie University, Canada
    • 1994 Labe Scheinberg Award, Multiple Sclerosis Consortium, Minnesota
    • 1993 Marvin Burke Studentship, Addiction Medicine Conference, Vancouver
    • 1992 Federation of Medical Women of Canada Bursary


    Research Group Members
    • Rhonda Ellwyn, B.A. - Research Coordinator
    • Elaine Chan, B.Sc. – Research Assistant
    • Dr. Daniel Lafleur - Child Psychiatry Clinician Scientist
    • Dr. Katherine McKenney – Child Psychologist, Pediatric OCD Program
    • Dr. Annie Simpson – Child Psychologist, Pediatric OCD Program
    • Dr. Andrea Boyle – Child Psychologist, Pediatric OCD Program
    • Noel Gregorowski, MSW – Social Worker, Pediatric OCD Program