• Ensom, Mary H. H. (formerly Chandler, MHH)

    Senior Associate Clinician Scientist, CFRI
    Professor and Director, Doctor of Pharmacy Program, Faculty of Pharmaceutical Sciences, and Distinguished University Scholar, The University of British Columbia
    Clinical Pharmacy Specialist, BC Children's Hospital and BC Women's Hospital & Health Centre
    Degrees / Designations
    BS(Pharm), PharmD, FASHP, FCCP, FCSHP
    Primary Area of Research
    Innovations in Acute Care & Technology
    Secondary Area(s) of Research
    Reproduction & Healthy Pregnancy
    Lab Phone
    Mailing Address
    Pharmacy Department
    BC Children's Hospital and BC Women's Hospital & Health Centre
    Room 0B7, 4500 Oak Street
    Vancouver, BC V6H 3N1
    Affiliate Websites
    Research Areas
    • Clinical pharmacokinetics (drug disposition) and pharmacodynamics (drug action)
    • Novel approaches to therapeutic drug monitoring
    • Hormonal influences and drug action and disposition in women
    • Pharmacogenetics
    • Pharmaceutical outcomes evaluations

    My long-term research focus has been in clinical pharmacokinetics (drug disposition) and pharmacodynamics (drug action), particularly as these disciplines relate to: women's health; effects of gender, age, and other pathophysiologic states on pharmacokinetics and pharmacodynamics; and novel approaches to therapeutic drug monitoring. More recent interests include pharmacogenetics and pharmaceutical outcomes evaluations. Every day I use my clinical practice experiences to identify relevant pharmacokinetic and pharmacodynamic problems that are then studied through my laboratory-based research program. As an integrator who bridges the gap between the basic and clinical sciences, my goal for my research program is to address these clinical problems from a qualitative, quantitative, and mechanistic perspective and to make a difference in the health and well-being of patients (i.e. study results are directly and immediately incorporated into patient care).

    Current Projects

    Pharmacokinetics and Pharmacodynamics of Intravenous Immunoglobulin (IVIG) Prior to and During Pregnancy in Patients with Unexplained Secondary Recurrent Spontaneous Abortion (RSA). This is the first study ever to evaluate the pharmacokinetics (study of what the body does to a drug) and pharmacodynamics (study of what drugs do to a body) prior to and during pregnancy in patients of intravenous immunoglobulin with recurrent pregnancy loss.

    Pharmacogenetics of Mycophenolate in Thoracic Transplant Recipients: Role of UDP-Glucuronosyltransferases. This study seeks to determine if the inter-patient variability observed in the mycophenolate pharmacokinetics of thoracic transplant recipients can be partially explained by genetic variability in the UDP-glucuronosyltransferase (UGT) enzymes responsible for its metabolism.

    Pharmacokinetics and Pharmacogenetics of Mycophenolate in Islet Cell Transplant Recipients. This project seeks to characterize the pharmacokinetics and pharmacogenetics of mycophenolic acid (MPA) and its glucuronidated metabolites and develop limited sampling strategies for this patient subpopulation.

    Stability of Medications in Extemporaneously Prepared Oral Suspensions for Use in Pediatric Patients. Most oral medications come in capsule or tablet form, many of which are prescribed to children (and to some adults) who cannot swallow capsules or tablets. As such, alternative dosage forms, primarily oral suspensions, need to be compounded extemporaneously and undergo stability testing to ensure effective drug delivery to patients and to give the suspensions a reasonable expiration date. In my lab, we evaluate the stability of various extemporaneously-compounded suspensions and apply the results immediately to care of pediatric patients.

    Selected Publications

    Out of a total of ~507 publications (including 236 articles in national and international peer-reviewed journals, 223 research abstracts, 3 books/monographs, 12 book chapters, and >30 other works)

    Burgess SV, Mabasa VH, Chow I, Ensom MH. 2015. Evaluating outcomes of alternative dosing strategies for cefepime: A qualitative systematic review. Ann Pharmacother 49(3):311-22. PMID: 25575975. DOI: 10.1177/1060028014564179.

    Carr RR, Decarie D, Ensom MH. 2014. Stability of epinephrine at standard concentrations. Can J Hosp Pharm 67(3):197-202. PMID: 24970939. PMCID: PMC4071081.

    Ensom MH and Decarie D. 2014. Stability of extemporaneously compounded dexamethasone in glass and plastic bottles and plastic syringes. Can J Hosp Pharm 67(4):274-9. PMID: 25214658. PMCID: PMC4152966.

    Kendrick JG, Ensom MH, Steer A, White CT, Kwan E, Carr RR. 2014. Standard-dose versus high-dose acyclovir in children treated empirically for encephalitis: A retrospective cohort study of its use and safety. Paediatr Drugs 16(3):229-34. PMID: 24497110. DOI: 10.1007/s40272-014-0066-4.

    Kiang TK, Hafeli UO, Ensom MH. 2014. A comprehensive review on the pharmacokinetics of antibiotics in interstitial fluid spaces in humans: Implications on dosing and clinical pharmacokinetic monitoring. Clin Pharmacokinet 53(8):695-730. PMID: 24972859. DOI: 10.1007/s40262-014-0152-3.

    Lo EA, Wilby KJ, Ensom MH. 2015. Use of proton pump inhibitors in the management of gastroesophageal varices: A systematic review. Ann Pharmacother 49(2):207-19. PMID: 25583938. DOI: 10.1177/1060028014559244.

    Ma C, Decarie D, Ensom MH. 2014. Stability of clonidine suspension in oral plastic syringes. Am J Health Syst Pharm 71(8):657-61. PMID: 24688040. DOI: 10.2146/ajhp130480.

    Reardon J, Lau TT, Ensom MH. 2015. Vancomycin loading doses: A systematic review. Ann Pharmacother. PMID: 25712445. DOI: 10.1177/1060028015571163.

    Turgeon RD, Wilby KJ, Ensom MH. 2014. Antiviral treatment of bell's palsy based on baseline severity: A systematic review and meta-analysis. Am J Med . PMID: 25554380. DOI: 10.1016/j.amjmed.2014.11.033.

    Kiang  TKL, Schmitt V, Ensom MHH, Chua B, Häfeli UO. Therapeutic Drug Monitoring in Interstitial Fluid: A Feasibility Study Using a Comprehensive Panel of Drugs. J Pharm Sci. 2012;101:4642-52. PMID: 22941939. DOI: 10.1002/jps.23309

    Pawluk SA, Wilby KJ, Ensom MHH. Pharmacokinetic-Profile of Artemisinin Derivatives and Companion Drugs Used in Artemisinin-based Combination Therapies for the Treatment of Plasmodium Falciparum Malaria in Children. Clin Pharmacokinet. 2013;52:153–167. PMID: 23288505. DOI: 10.1007/s40262-012-0026-5.

    Ensom MHH. What Will It Take?: The Quest to Achieve Indexing by the National Library Of Medicine. Can J Hosp Pharm. 2013;66:4-5.

    Cartwright AL, Wilby KJ, Corrigan S, Ensom MHH. Pharmacogenetics of Risperidone: A Systematic Review of the Clinical Effects of CYP2D6 Polymorphisms. Ann Pharmacother. 2013;47:350-60. PMID: 23463739. DOI: 10.1345/aph.1R333

    Wilby KJ, Gilchrist SE, Ensom MHH. A Review of the Pharmacokinetic Implications of Schistosomiasis. Clin Pharmacokinet. 2013 Aug;52(8):647-56. PMID: 23479397. DOI 10.1007/s40262-013-0055-8

    Culley C, Kiang TKL, Gilchrist SE, Ensom MHH. Effect of the UGT1A1*28 Allele on Unconjugated Hyperbilirubinemia in HIV Patients Receiving Atazanavir: A Systematic Review. Ann Pharmacother. 2013;47: 561-72. PMID: 23548653. DOI: 10.1345/aph.1R550

    Ramsey T, Lau TTY, Ensom MHH. Linezolid’s Serotonergic and Adrenergic Drug Interactions: A Critical Review and Practical Management Approach. Ann Pharmacother. 2013;47:543-60. PMID: 23548646. DOI: 10.1345/aph.1R604

    Kiang TKL, Wilby KJ, Ensom MHH. Telaprevir: Clinical Pharmacokinetics, Pharmacodynamics, and Drug-Drug Interactions. Clin Pharmacokinet. 2013; Published Ahead of Print 4 April. PMID: 23553423. DOI 10.1007/s40262-013-0053-x

    Ensom MHH, Kendrick J, Rudolph S, Decarie D. Stability of Propranolol in Extemporaneously Compounded Suspensions. Can J Hosp Pharm. 2013;66:118-24. PMID: 23616676. PMCID: PMC3633496.

    Honours & Awards

    Out of >75 awards for scholarship, research, and service, including 10 outstanding teacher awards

    Inaugural Class (n=4) of Hall of Distinguished Alumni, University of Kentucky College of Pharmacy (2015)

    Distinguished Service Award, B.C. Branch Canadian Society of Hospital Pharmacists (C.S.H.P.), given to an individual "who has shown significant and extensive contribution to hospital pharmacy at the local, provincial, and national levels" (2014)

    Class of 2014 Master Teacher Award, Faculty of Pharmaceutical Sciences, UBC (2014)

    2014 Pharmacotherapy Best Practices Award (Merck), C.S.H.P.

    Paul F. Parker Award, University of Kentucky (2013)

    Visionary Award, UBC Pharmaceutical Sciences Student Journal (2013)

    2012 Publication Award (Review Article category), B.C. Branch - Canadian Society of Hospital Pharmacists (C.S.H.P.)* [*Note: Only 2 Awards are available each year - one Original Research and one Review Article - M Ensom's group received both Awards in 2011 and also was the recipient of the Publication Award (Review Article or Original Research category) in 1998, 2005, 2006, 2007, and 2008.]

    2012 American Society of Health-System Pharmacists Foundation's Award for Sustained Contributions to the Literature "for significant contributions to the biomedical literature over the course of her career" (first Canada-based individual to receive this award from ASHP, a 40,000+ member organization; received award at the 2012 ASHP Midyear Clinical Meeting, the world's largest gathering of 20,000+ pharmacy professionals).

    American Society of Health-System Pharmacists (ASHP) Foundation 2012 Award for Sustained Contributions

    Publication Award, B.C. Branch (Review Article Category) C.S.H.P. - 2011

    Publication Award, B.C. Branch (Original Research Category) C.S.H.P. - 2011

    American College of Clinical Pharmacy (ACCP) Education Award "for major contributions to advancing clinical pharmacy education" - 2011

    Bristol-Myers Squibb Award for Excellence in Pharmaceutical Teaching, UBC - 2011

    Specialties in Pharmacy Practice Award (Hospira Healthcare Corporation), C.S.H.P. - 2011

    Specialties in Pharmacy Practice Award (Bristol-Myers Squibb Canada), C.S.H.P. - 2011

    Publication Award, B.C. Branch C.S.H.P. - 2010

    Best Paper Award Finalist/First Runner-Up (“The Great Eight”), American College of Clinical Pharmacy 2010 Annual Meeting

    Rho Chi Lecturer, University of Kentucky College of Pharmacy - 2010

    Best Paper Award Finalist/First Runner-Up (“The Great Eight”), American College of Clinical Pharmacy 2009 Annual Meeting

    Class of 2009 Master Teacher Award, UBC - 2009

    Specialties in Pharmacy Practice Award, C.S.H.P. -2009

    Publication Award, B.C. Branch C.S.H.P. - 2008

    UBC Killam Research Prize (in Science Category) - 2008

    Publication Award, B.C. Branch C.S.H.P. - 2007

    Fellow, Canadian Academy of Health Sciences, FCAHS -2007

    Publication Award, B.C. Branch C.S.H.P. - 2006

    American College of Clinical Pharmacy Russell R Miller Publication Award, “in recognition of sustained and outstanding contributions to the literature of clinical pharmacy, thereby advancing both clinical pharmacy practice and rational pharmacotherapy” - 2006

    Publication Award, B.C. Branch C.S.H.P. - 2005

    UBC Distinguished University Scholar – 2003

    Best Poster Award (1st place), American College of Clinical Pharmacy 2003 Annual Meeting

    Best Poster Award (1st place), Canadian College of Clinical Pharmacy 2003 Annual Meeting

    Fellow, Canadian Society of Hospital Pharmacists, FCSHP – 2003

    ACPA Service Award, American Chinese Pharmaceutical Association – 2002

    Bristol-Myers Squibb Excellence in Teaching Award – 2001

    UBC Killam Teaching Prize – 2000

    Pfizer Pharmacy Practice Award, B.C. Branch C.S.H.P. – 2000

    Research Group Members
    Diane Decarie - Lab technician
    Tony KL Kiang - Postdoctoral fellow