• Poskitt, Kenneth

    Titles
    Associate Clinician Scientist, CFRI
    Pediatric Neuroradiologist, BC Children’s Hospital
    Assistant Professor, Department of Pediatrics, University of British Columbia
    Degrees / Designations
    MDCM
    Primary Area of Research
    Developmental Neurosciences & Child Health
    Secondary Area(s) of Research
    Phone
    604-875-2345 x4792
    Fax
    604-875-3467
    Lab Phone
    604-875-2345 x4792
    Mailing Address
    Room L314, 4480 Oak Street, Vancouver, BC, V6H 3V4
    Affiliate Websites
    Research Areas
    • Neuroimaging
    Summary

    Dr. Poskitt's clinical and academic focus has centered around neuro-imaging of the developing brain. Acquired brain injuries from insults such as infection birth asphyxia, trauma and congenital heart defects are studied to understand the impact on brain development and neurological outcome. As a member of CFRI, Dr. Poskitt participates in primary research in collaboration with other members of the Developmental Neurosciences & Child Health group. His other mandate from CFRI is to make himself and his knowledge of imaging techniques available to any CFRI Researcher whose project might be advanced by including an imaging component to the study design. Dr. Poskitt is also playing an instrumental role in the development of the 3T Imaging Research Facility to be built at Children's & Women's.

    Current Projects

    In conjunction with Dr. Steven Miller long term studies on the impact of neuro-development in two at risk groups have been initiated: premature infants and infants born with congenital heart defects.  These studies entail a large component of serial MR imaging to detect injury but also apply more advanced MR imaging techniques such as DTI imaging and MR spectoscopy in an effort to quantify the effects of different variables on the development, structure and function on the infant brain.  These techniques have been applied on identified fetuses know to be at risk as well as other cohorts suffering from some form of acquired brain injury such as those that accompany chronic renal disease or radiation and chemotherapy in patients suffering from brain tumors.

    A second group of subjects that have been the focus of extensive long term investigation are infants born who are at risk of brain injury secondary to Hypoxic ischemic encephalopathy at the time of delivery.  The neonatal neurology group at BCCH has a 20-year history of working with imaging, both CT and MRI, to outline the imaging correlates of different types of birth asphyxia.  Most recently efforts have been undertaken to study the utility of early, (between 12 and 24 hours), diffusion weighted imaging, FA maps and MR spectroscopy in the identification and stratification of brain injury.  These studies have entailed serial MR imaging without sedation of infants at risk.  More recent efforts have been made to expand this group by developing a working partnership with Children's National Medical Center in Washington, DC.

    Selected Publications

    Brummelte S, Grunau RE, Chau V, Poskitt KJ, Brant R, Vinall J, Gover A, Synnes AR, Miller SP. Procedural pain and brain development in premature newborns. Ann Neurol. 2012 Mar;71(3):385-96. doi: 10.1002/ana.22267. Epub 2012 Feb 28. PMID: 22374882

    Chau V, Brant R, Poskitt KJ, Tam EW, Synnes A, Miller SP. Postnatal infection is associated with widespread abnormalities of brain development in premature newborns. Pediatr Res. 2012 Mar;71(3):274-9. doi: 10.1038/pr.2011.40. Epub 2012 Jan 25. PMID: 22278180

    Tam EW, Chau V, Ferriero DM, Barkovich AJ, Poskitt KJ, Studholme C, Fok ED, Grunau RE, Glidden DV, Miller SP. Preterm cerebellar growth impairment after postnatal exposure to glucocorticoids. Sci Transl Med. 2011 Oct 19;3(105):105ra105. PMID: 22013125

    Glass HC, Bowman C, Chau V, Moosa A, Hersh AL, Campbell A, Poskitt K, Azakie A, Barkovich AJ, Miller SP, McQuillen PS. Infection and white matter injury in infants with congenital cardiac disease. Cardiol Young. 2011 Oct;21(5):562-71. Epub 2011 Apr 19. PMID: 21554828

    Doesburg SM, Ribary U, Herdman AT, Moiseev A, Cheung T, Miller SP, Poskitt KJ, Weinberg H, Whitfield MF, Synnes A, Grunau RE. Magnetoencephalography reveals slowing of resting peak oscillatory frequency in children born very preterm. Pediatr Res. 2011 Aug;70(2):171-5. PMID: 21544009

    Block AJ, McQuillen PS, Chau V, Glass H, Poskitt KJ, Barkovich AJ, Esch M, Soulikias W, Azakie A, Campbell A, Miller SP. Clinically silent preoperative brain injuries do not worsen with surgery in neonates with congenital heart disease. J Thorac Cardiovasc Surg. 2010 Sep;140(3):550-7. PMID: 20434174

    Adams E, Chau V, Poskitt KJ, Grunau RE, Synnes A, Miller SP Tractography-based quantitation of corticospinal tract development in premature newborns. J Pediatr. 2010 Jun;156(6):882-8, 888.e1. PMID: 20227731

    Lehman AM, Schultz KR, Poskitt K, Bjornson B, Keyes R, Waters PJ, Clarke LA, Everett R, McConnell D, Stockler S. Intracranial calcification after cord blood neonatal transplantation for krabbe disease. Neuropediatrics. 2009 Aug;40(4):189-91. PMID: 20135576

    du Souich C, Chou A, Yin J, Oh T, Nelson TN, Hurlburt J, Arbour L, Friedlander R, McGillivray BC, Tyshchenko N, Rump A, Poskitt KJ, Demos MK, Van Allen MI, Boerkoel CF. Characterization of a new X-linked mental retardation syndrome with microcephaly, cortical malformation, and thin habitus. Am J Med Genet A. 2009 Nov;149A(11):2469-78. PMID: 19842190

    Chau V, Poskitt KJ, McFadden DE, Bowen-Roberts T, Synnes A, Brant R, Sargent MA, Soulikias W, Miller SP. Effect of chorioamnionitis on brain development and injury in premature newborns. Ann Neurol. 2009 Aug;66(2):155-64. PMID: 19743455

    Ludemann JP, Poskitt K, Singhal A. Intracranial hypertension secondary to sigmoid sinus compression by group A streptococcal epidural abscess. J Laryngol Otol. 2010 Jan;124(1):93-5. Epub 2009 Aug 3. PMID: 19646300

    Grants
    Honours & Awards

    1995 -  Am. Ass. Of Publisher’s Best Book in Clinical Medicine "Congenital Malformations of the Brain”

    1986-1987 - R S McLaughlin Foundation Fellowship

    1977-1981 - Scholarship McGill Medicine

    Research Group Members