• Scheifele, David W.

    Titles
    Senior Clinician Scientist, CFRI
    Director, Vaccine Evaluation Center, CFRI
    Professor, Division of Infectious and Immunological Diseases, Department of Pediatrics, University of British Columbia
    Degrees / Designations
    O.C., MD, FRCP(C)
    Primary Area of Research
    Immunity in Health & Disease
    Secondary Area(s) of Research
    Phone
    604-875-2422
    Fax
    604-875-2635
    Lab Phone
    Assistant
    Cecilia Jankowski
    Assistant Phone
    604-875-2422
    Mailing Address
    BC Children's Hospital
    950 West 28th Avenue
    Vancouver, BC V5Z 4H4
    Research Areas
    • Vaccines and immunization
    • Epidemiology of vaccine-preventable infections
    • Vaccine safety
    • Immunization program evaluation
    Summary
    I am Director of the Vaccine Evaluation Center, a leading centre for applied vaccine research in Canada. Six researchers contribute to the VEC’s core research program, including S. Dobson, T. Kollmann, L. Sauvé, J. Bettinger, S.Gantt, and several more collaborate from other local institutions (BCCDC, VCHA). The researchers share a field team (coordinators, nurses, assistants), data management group (manager, statistician, assistants) and specialized laboratory. The main research themes involve disease burden studies, vaccine clinical trials, and studies to fine tune public immunization programs, including ongoing assessment of vaccine safety. The Vaccine Center researchers collaborate with vaccine specialists across the country and with provincial and federal health officials, with the goal of efficiently translating new vaccine products into optimal vaccination programs for children and adults.
    Current Projects

    I am the data centre supervisor for the Immunization Monitoring Program, Active (IMPACT), an active surveillance program involving 12 pediatric centers across Canada. This project is funded by the Public Health Agency of Canada and operated by the Canadian Pediatric Society and its specialist members in infectious diseases. Nurse monitors at each hospital actively search for admissions with adverse events following immunization, to assess causes and outcomes. This is a key means of assessing vaccine safety, particularly the occurrence of uncommon, severe reactions. Monitors also report on selected vaccine preventable diseases, as a measure of vaccine program effectiveness. Surveillance presently includes varicella, pertussis, invasive pneumococcal, meningococcal rotavirus and influenza admissions.

    I was co-leader of the PHAC/CIHR Influenza Research Network (PCIRN), responsible for the Clinical Trials activities. PCIRN was established in April 2009 to prepare for necessary investigations during an influenza pandemic and was quickly re-tasked in May 2009 to focus on the H1N1 pandemic. The PCIRN network carried out 4 trials of pH1N1 vaccine in late 2009 involving over 700 subjects at 13 centers across Canada. Related studies continued in 2010 and 2011, the legacy from which will be an advanced state of preparedness for studies in a public health emergency.

    Selected Publications

    Sadarangani M, Scheifele DW, Halperin SA, Vaudry W, Le Saux N, Tsang R, Bettinger JA, investigators of the Canadian Immunization Monitoring Program, ACTive (IMPACT), investigators of the Canadian Immunization Monitoring Program ACTive IMPACT. 2015. Outcomes of invasive meningococcal disease in adults and children in Canada between 2002 and 2011: A prospective cohort study. Clin Infect Dis 60(8):e27-35. DOI: 10.1093/cid/civ028. PMID: 25605282

    Bettinger JA, Scheifele DW, Halperin SA, Vaudry W, Findlow J, Borrow R, Medini D, Tsang R, for the members of the Canadian Immunization Monitoring Program, Active (IMPACT). Diversity of Canadian meningococcal serogroup B isolates and estimated coverage of an investigational meningococcal serogroup B vaccine (4CmenB). Vaccine 2014; 32(1):124-130. PMID: 23588089

    Scheifele DW, Ward BJ, Halperin SA, McNeil SA, Crowcroft NS, Bjornson G. Approved but non-funded vaccines: Accessing individual protection. Vaccine 2014; 32(7):766-770. PMID: 24374500

    Omura J, Buxton J, Kaczorowski J, Catterson J, Li J, Derban A, Hasselback P, Machin S, Linekin M, Morgana T, O’Briain B, Scheifele D, Dawar M. Immunization delivery in British Columbia – Perspectives of primary care physicians. Can Fam Physician 2014; 60(March):e187-e193. PMID: 24627403

    Yam KK, Gipson E, Klein M, Walmsley S, Haase D, Halperin S, Scheifele D, Ward BJ, Cooper C. High level antibody avidity is achieved in HIV-seropositive recipients of an inactivated split adjuvanted (AS03A) influenza vaccine. J Clin Immunol 2014; 34:655-662. PMID: 24824648

    Bettinger JA, Halperin SA, Vaudry W, Law BJ, Scheifele DW, on behalf of the Canadian IMPACT members. The Canadian Immunization Monitoring Program, ACTive (IMPACT): Active surveillance for vaccine adverse events and vaccine-preventable diseases. CCDR 2014;40 S-3.

    Burton C, Vaudry W, Moore D, Bettinger JA, Tran D, Halperin SA, Scheifele DW, IMPACT investigators. 2014. Burden of seasonal influenza in children with neurodevelopmental conditions. Pediatr Infect Dis J 33(7):710-4. DOI: 10.1097/INF.0000000000000272. PMID: 24918745

    Pinto M and Scheifele D. 2014. Discussing the need for an adolescent Hepatitis B vaccine booster in infant vaccinees. Paediatr Child Health 19(8):404. PMCID: PMC4220521. PMID: 25382994 

    Sadarangani M, Scheifele DW, Halperin SA, Vaudry W, Le Saux N, Tsang R, Bettinger JA, investigators of the Canadian Immunization Monitoring Program, ACTive (IMPACT). 2014. The impact of the Meningococcal serogroup C conjugate vaccine in Canada between 2002 and 2012. Clin Infect Dis 59(9):1208-15. DOI: 10.1093/cid/ciu597. PMID: 25069868

    Scheifele DW, Halperin SA, Bettinger JA. 2014. Childhood immunization rates in canada are too low: UNICEF. Paediatr Child Health 19(5):237-8. PMCID: PMC4029243.PMID: 24855424

    Scheifele DW, Ferguson M, Predy G, Dawar M, Assudani D, Kuriyakose S, Van Der Meeren O, Han HH. 2015. Immunogenicity and safety of 3-dose primary vaccination with combined DTPa-HBV-IPV/Hib vaccine in Canadian aboriginal and non-aboriginal infants. Vaccine. DOI:  10.1016/j.vaccine.2015.02.015. PMID: 25701314

    Thollot F, Scheifele D, Pankow-Culot H, Cheuvart B, Leyssen M, Ulianov L, Miller JM. 2014. A randomized study to evaluate the immunogenicity and safety of a heptavalent diphtheria, tetanus, pertussis, hepatitis B, poliomyelitis, haemophilus influenzae b, and meningococcal serogroup C combination vaccine administered to infants at 2, 4 and 12 months of age. Pediatr Infect Dis J 33(12):1246-54. DOI: 10.1097/INF.0000000000000468. PMID: 25037033

    Schneeberg A, Bettinger JA, McNeil S, Ward BJ, Dionne M, Cooper C, Coleman B, Loeb M, Rubinstein E, McElhaney J, et al (Scheifele DW). 2014. Knowledge, attitudes, beliefs and behaviours of older adults about pneumococcal immunization, a public health agency of Canada/Canadian institutes of health research influenza research network (PCIRN) investigation. BMC Public Health 14:442,2458-14-442. PMCID: PMC4046143. DOI: 10.1186/1471-2458-14-442. PMID: 24884433

    Bettinger JA, Scheifele DW, Halperin SA, Kellner JD, Vanderkooi OG, Schryvers A, De Serres G, Alcantara J. Evaluation of meningococcal serogroup C conjugate vaccine programs in Canadian children: interim analysis. Vaccine. 2012 Jun 8;30(27):4023-7. doi: 10.1016/j.vaccine.2012.04.034. Epub 2012 Apr 23. PMID: 22537988

    Scheifele D W, Marty K, LaJeunesse C, Fan SY, Bjornson G, Langley JM, Dobson S, Li Y, Law B, Halperin SA. Evaluation of Adjuvanted Pandemic H1N1 2009 Influenza Vaccine after one and two doses in young children. PIDJ 2011;30:402-7. PMID: 21178654

    Rubinstein E, Predy G, Sauvé, Hammond G W, Aoki F, Sikora C, Li Y, Law B, Halperin SA, Scheifele D. The responses of Aboriginal Canadians to adjuvanted pandemic (H1N1) 2009 influenza vaccine. CMAJ 2011;183(13):E1033-E1037. PMID: 21788422

    Bettinger J A, Sceifele D W, Kellner J D, et al. The effect of routine vaccination on invasive pneumococcal infections in Canadian children, Immunization Monitoring Program, Active 2000-2007. Vaccine 2010;28:2130-2136. PMID: 20044050

    Bettinger J A, Sauvé LJ, Sceifele D W, Moore D, Vaudry W, Tran D, Halperin S A, Pelletier L. Pandemic influenza in Canadian children: A summary of hospitalized pediatric cases. Vaccine 2010;28:3180-3184. PMID: 20189488

    Scheifele D W, De Serres G, Gilca V, Duval B, Milner R, Ho M, Ochnio J J. A nationwide survey of past hepatitis A infections among Canadian adults. Vaccine 2010;28:6174-78. PMID: 20558251

    Scheifele D W, Ochnio J J, Halperin S A. Cellular Immunity as a Potential Cause of Local Reactions to Booster Vaccination with Diphtheria and Tetanus Toxoids and Acellular Pertussis Antigens. PIDJ 2009;28:985-9. PMID: 19755930

    Bettinger JA, Scheifele DW, Le Saux N, Halperin SA, Vaudry W, Tsang R; Canadian Immunization Monitoring Program, Active (IMPACT).: The impact of childhood meningococcal serogroup C conjugate vaccine programs in Canada. Pediatr Infect Dis J. 2009 Mar;28(3):220-4. PMID: 19209096

    Scheifele D W. IMPACT after 17 years: Lessons learned about successful networking. Paediatr Child Health 2009; 14:33-5. PMID: 19436462

    Scheifele DW, Bettinger JA, Halperin SA, Law B, Bortolussi R.: Ongoing control of Haemophilus influenzae type B infections in Canadian children, 2004-2007. Pediatr Infect Dis J. 2008 Aug;27(8):755-7. PMID: 18594482

    Wootton SH, Law B, Tan B, Mozel M, Scheifele DW, Halperin S for IMPACT Investigators.: The epidemiology of children hospitalized with herpes zoster in Canada - Immunization Monitoring Program, Active (IMPACT), 1991-2005. Pediatr Infect Dis J. 2008 Feb; 27(2):112-118. PMID: 18174867

    Scheifele D W, Halperin S A, Ward B, Duval B. The challenges facing Canadian trialists in an increasingly competitive global market: what can be done to remain competitive? Can J Infect Dis Med Microbiol 2007; 18:205-8. PMID: 18923723

    Bettinger J A, Scheifele D W, Halperin S A, Kellner J D, Tyrell G and Members of the Canadian Paediatric Society's Immunization Monitoring Program, Active (IMPACT). Invasive pneumococcal infections in Canadian children, 1998-2003. Can J Pub Hlth 2007; 98:111-115. PMID: 17441533

    Bjornson G, Scheifele D W, Bettinger J, Patrick D M, Gustafson L, Daly P and Tyrell G J. Effectiveness of pneumococcal conjugate vaccine in Greater Vancouver, Canada: 2004-2005. Ped Infect Dis J 2007; 26(6):540-542. PMID: 17529875

    Scheifele D W, Halperin S A, Ochnio J J, Ferguson A C, Skowronski D M. A modified vaccine reduces the rate of large injection site reactions to the preschool booster dose of diphtheria-tetanus acellular pertussis vaccine - results of a randomized, controlled trial. Pediatr Infect Dis J 2005: 24(12)3:28-51 PM 1059-1066. PMID: 16371866

    Scheifele D W, Duval B, Russell M L, Warrington R, De Serres G, Skowronski d M, Dionne M, Kellner J, Davies D, MacDonald J. Ocular and respiratory symptoms attributable to inactivated split influenza vaccine: evidence from a controlled trial involving adults. Clin Infect Dis 2003 Apr 1; 36(7):850-7. Epub 2003 Mar 18. PMID: 12652385

    Grants
    Honours & Awards

    Officer of the Order of Canada – 2013

    Queen Elizabeth II Golden Jubilee Medal – 2013

    Royal College Lecturer, Canadian Paediatric Society Annual Conference - 2011

    Distinguished Lecture in Canadian Immunization, Canadian Immunization Conference –
    2010

    CIHR/Wyeth Chair in Clinical Vaccine Research – 2004-2009

    Alan Ross Award, Canadian Paediatric Society – 2007

    Sauder Chair in Pediatric Infectious Diseases – 1997-2004

    Research Group Members
    • Cecilia Jankowski – Secretary
    • Gordean Bjornson – Finance/Research Associate
    • Simonetta Leduc – Research Office Administrator
    • Arlene Kallos – Clinical Trial Unit Manager
    • Carol LaJeunesse – Special Projects Facilitator
    • Kathy Leung – Research Nurse 
    • Karen Kroeker – IMPACT Monitor/Research Nurse 
    • Engy Grove – Research Assistant
    • Ashley Cosgrove – Research Assistant
    • Tanya Bajwa – Research Assistant, Technician
    • Kim Marty – Senior Data Team Manager
    • Wenli Zhang – Data Coordinator
    • Shuyu Fan – Statistician
    • Brittany Seligman – Research Assistant
    • Claire Pitcher – Research Nurse
    • Emily Rousseau – Research Assistant
    • Ivor Chee – Research Nurse
    • Jennifer Smith – Research Assistant
    • Jessica Coffey – Research Assistant
    • Kendra Wong – Research Assistant
    • Marie Campbell – Research Nurse
    • Michelle Mozel – Data Coordinator
    • Sarah McCann – Research Nurse
    • Sophia Bobovski – Research Assistant